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Ex vivo Electrical Impedance Measurements on Human Liver Samples with Metastatic Colorectal Cancer

What are the differences in electrical properties of human liver tissue? Find out in our new publication "Ex vivo electrical impedance measurements on excised hepatic tissue from human patients with metastatic colorectal cancer" published in The Journal of Physiological Measurement by S. Prakash, M. P. Karnes, E. K. Sequin, J. D. West, C. L. Hitchcock, S. D. Nichols, M. Bloomston, S. R. Abdel-Misih, C. R. Schmidt, E. W. Martin Jr, S. P. Povoski and V. V. Subramaniam. Read all about it in our paper here.


Abstract: Point-wise ex vivo electrical impedance spectroscopy measurements were conducted on excised hepatic tissue from human patients with metastatic colorectal cancer using a linear four-electrode impedance probe. This study of 132 measurements from 10 colorectal cancer patients, the largest to date, reports that the equivalent electrical conductivity for tumor tissue is significantly higher than normal tissue (p  <  0.01), ranging from 2–5 times greater over the measured frequency range of 100Hz–1MHz. Difference in tissue electrical permittivity is also found to be statistically significant across most frequencies. Furthermore, the complex impedance is also reported for both normal and tumor tissue. Consistent with trends for tissue electrical conductivity, normal tissue has a significantly higher impedance than tumor tissue (p < 0.01), as well as a higher net capacitive phase shift (33° for normal liver tissue in contrast to 10° for tumor tissue)